65 to 70% of total iron enters in haemoglobin composition ; 20 to 25% is stored in cells thanks to ferritin. Plasma contains about 3 mg of iron bound to transferrin.
Serum iron concentration increases in case of hemochromatosis, liver damage and iron intoxication. Decreased iron levels can be the consequence of increased needs, dietary deficiency, bleeding, or an impaired absorption (gastro-intestinal disorders, malabsorption). Serum iron level will always be interpreted with transferrin saturation data.
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